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Cat. No.: HY-P11837

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NECT-224

NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga.

For research use only. We do not sell to patients.

Formula: C₁₁₃H₁₅₃N₂₇O₃₃S₃
Molecular Weight:2513.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

NECT-224 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NECT-224 is a bifunctional chelator and a nectin-4 targeting peptide conjugate. NECT-224 can be used as a PET imaging agent when labeled with ⁶⁴Cu or ⁶⁸Ga^[1]^[2].

In Vitro

NECT-224 binds to recombinant human nectin-4 with a dissociation constant of 1.64 nM, demonstrating high target affinity^[1].
NECT-224 binds to the Ig-like V domain of nectin-4, forming the basis for radiotracers enabling tumor imaging^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2513.78
Formula C₁₁₃H₁₅₃N₂₇O₃₃S₃
Sequence

NODAGA-Cys-Pro-{1Nal}-{d-Asp}-Cys-{Mox}-{hArg}-Asp-Trp-Ser-Thr-Pro-{Hyp}-Trp-Cys-NH2 (TATA?covalent?with?Cys1,Cys5,Cys15)
Sequence Shortening

NODAGA-CP-{1Nal}-{d-Asp}-C-{Mox}-{hArg}-DWSTP-{Hyp}-WC-NH2 (TATA covalent with Cys1,Cys5,Cys15)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Krönke T, et al. "Precision on Two Wheels"─Structural Refinement of ⁶⁴Cu- and ⁶⁸Ga-Labeled Bicyclic Peptides Targeting Nectin-4 for Improved Tumor Imaging: From Preclinical Development to First-in-Human Application. J Med Chem. 2025;68(20):21962-21987. [Content Brief]

[2]. H Ou, et al. Cutting-edge advances in bicyclic peptide-based radiotracers for cancer imaging and theranostics. VIEW.2026, 7, 20250181.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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