F11r - F11 receptor Gene

Also Known as JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; 9130004G24

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16456

Summary

Predicted to enable PDZ domain binding activity; Integrin binding activity; and protein homodimerization activity. Involved in intestinal absorption; regulation of cytokine production; and regulation of membrane permeability. Acts upstream of or within cell adhesion and epithelial cell differentiation. Located in bicellular tight junction. Is expressed in several structures, including 4-8 cell stage embryo; alimentary system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human F11R (F11 receptor). [provided by Alliance of Genome Resources, Apr 2022]

F11r Products (1)

mRNA Protein Name
NM_172647.2 NP_766235.1 junctional adhesion molecule A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11689568 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
15494378 MGI
acts upstream of or within epithelial cell differentiation IDA
IDA: Inferred from direct assay
15494378 MGI
involved in intestinal absorption IMP
IMP: Inferred from mutant phenotype
23885123 MGI
involved in regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
18514073 MGI
involved in regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
23885123 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IMP
IMP: Inferred from mutant phenotype
15494378 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junctional adhesion molecule A

  • BV11 antigen

  • F11 receptor/F11R

  • junction cell adhesion molecule A

  • junction cell adhesion molecule1

  • junctional adhesion molecule 1

Recombinant F11r Proteins

Cat. No. Product Name Accession Purity
HY-P73855 JAM-A/CD321 Protein, Mouse (HEK293, Fc) O88792 (K27-A242) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78322 JAM-A/CD321 Protein, Mouse (HEK293, His) O88792 (K27-G238) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04626 F11R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19600 F11r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26096 F11r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F11r NCBI NCBI:50848