F11R - F11 receptor Gene

Homo sapiens

Also known as JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1

Gene ID: 50848 | Gene type: protein coding

About F11R

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,995,211-161,021,152 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 14 paralogues. Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues.

Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the Integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

F11R Products(6)

mRNA	Protein	Name
NM_001348091.2	NP_001335020.1	junctional adhesion molecule A isoform 6 precursor
NM_001382727.1	NP_001369656.1	junctional adhesion molecule A isoform 7 precursor
NM_001382730.1	NP_001369659.1	junctional adhesion molecule A isoform 8 precursor
NM_001382733.1	NP_001369662.1	junctional adhesion molecule A isoform 9 precursor
NM_001382734.1	NP_001369663.1	junctional adhesion molecule A isoform 10 precursor
NM_016946.6	NP_058642.1	junctional adhesion molecule A isoform 1 precursor

F11R Protein Structure

V-set

Ig_2

0
100
200
299 a.a.

Protein Preferred Names

Protein Names

junctional adhesion molecule A

junctional adhesion molecule 1

Recombinant F11R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70948	JAM-A/CD321 Protein, Human (HEK293, His)	Q9Y624 (S28-V238)	≥95%

Related Diseases

Diseases

Alias

Nemaline Myopathy 4

Cap Myopathy 2	NEM4
Nemaline Myopathy 4, Autosomal Dominant	Nemaline Myopathy, Type 4
CAPM2	Cap Disease
Cap Myopathy Tpm2-Related	Tpm2-Related Nemaline Myopathy
Tpm2-Related Cap Myopathy	Myopathy, Nemaline, Type 4
Cap Myopathy

Purulent Acute Otitis Media

Acute Suppurative Otitis Media	Acute Or Subacute Suppurative Otitis Media
Acute Or Subacute Purulent Otitis Media

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04626	F11R Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	F11R	VGNC	VGNC:56143
Macaca mulatta	F11R	VGNC	VGNC:72272
Mus musculus	F11R	MGD	MGI:1321398
Bos taurus	F11R	VGNC	VGNC:50010
Felis catus	F11R	VGNC	VGNC:109510
Rattus norvegicus	F11R	RGD	RGD:621842
Others	F11R	NCBI