Art. -Nr.: HY-N2115

Araloside A

(Synonyms: Chikusetsusaponin IV)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

Araloside A (Chikusetsusaponin IV), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A shows low-renin-inhibitory activity with an IC₅₀ of 77.4 μM. Araloside A can inhibit cell proliferation and induce apoptosis. Araloside A suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis.

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Reinheit: 99.86%
CAS. Nr.: 7518-22-1
Formel: C₄₇H₇₄O₁₈
Molecular Weight:927.08

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Araloside A Chemical Structure

CAS. Nr.: 7518-22-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 77.4 μM (Renin)^[1]

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Araloside A (1-100 μM, 24-72 h) reduces cellular viability and induces apoptosis in GRC-1 and 786-O cells^[2].
Araloside A (1-32 μM, 24 h) inhibits proliferation in MH7A cells^[3].
Araloside A (4-16 μM, 24 h) induces apoptosis in MH7A cells^[3].
Araloside A (4-16 μM, 24 h) suppresses IL-1β, IL-6, NO and PGE2 levels and inhibits NF-κB pathway in MH7A cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

GRC-1 and 786-O cells
Concentration:

1, 3, 10, 30 and 100 μM
Incubation Time:

24, 48 and 72 h
Result:

Increased the percentage of TUNNEL-positive cells.
Increased bax mRNA expression and decreased bcl-2 mRNA levels.

Apoptosis Analysis^[3]

Cell Line:

MH7A cells
Concentration:

4, 8, 16 μM
Incubation Time:

24 h
Result:

Increased apoptotic rate and caspase-3/7 activity.
Increased Cyt C level and decreased Bcl-2 level.

Western Blot Analysis^[3]

Cell Line:

MH7A cells
Concentration:

4, 8, 16 μM
Incubation Time:

24 h
Result:

Declined p-NF-κB p65 and p-IκBα expressions.

In Vivo

Araloside A (10-40 mg/kg, i.g., daily for 7 days) shows protective effect in gastric ulcer mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ethanol‑ and aspirin‑induced gastric ulcer mice models^[1]
Dosage:

10, 20 and 40 mg/kg
Administration:

Orally gavage, daily for 7 days
Result:

Markedly raised the gastric juice volume and acidity.
Ameliorated the gastric mucosal blood flow and gastric binding mucus volume.
Increased inhibitory rate.
Inhibited H+/K+-ATPase activities.
Increased Bcl-2 levels and decreased caspase‑3, caspase‑9, Apaf 1 and PARP 1 levels.

Chemical Information

CAS. Nr. 7518-22-1
Appearance Solid
Molecular Weight 927.08
Formel C₄₇H₇₄O₁₈
Color White to off-white
SMILES

O=C([C@]1(CCC(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]6O[C@]7([H])O[C@@H](CO)[C@H](O)[C@H]7O)O)([H])O[C@@H]6C(O)=O)C5(C)C)C)[C@]3(C)CC1)O[C@@H]([C@@H]([C@@H](O)[C@@H]8O)O)O[C@@H]8CO
Synonyms

Chikusetsusaponin IV
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Plants
- other families
- Plants
- Araliaceae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Food Sci Nutr

From Wild Vegetable to Renal Protector: The Therapeutic Potential of Aralia elata (Miq.) Seem. [Abstract]

2025 Nov 17;13(11):e71212. PMID: 41256226
J Nat Med

Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells. [Abstract]

2025 Jul;79(4):922-930. PMID: 40335793

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (107.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0787 mL

5.3933 mL

10.7866 mL

5 mM

0.2157 mL

1.0787 mL

2.1573 mL

10 mM

0.1079 mL

0.5393 mL

1.0787 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 1.25 mg/mL (1.35 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 1.25 mg/mL (1.35 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (1.35 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Takahashi S, et al. Inhibition of human renin activity by saponins. Biomed Res. 2010 Apr;31(2):155-9. [Content Brief]

[2]. Liu Y, et.al. The antitumor effects of Araloside A extracted from the root bark of Aralia elata on human kidney cancer cell lines. African Journal of Pharmacy and Pharmacology Vol. 5(4), pp. 462-467, April 2011.

[3]. Ding Y, et.al. Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes. Chem Biol Interact. 2019 Jun 1;306:131-137. [Content Brief]

[4]. He H, et al. Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway. J Nat Med. 2019 Mar;73(2):339-352. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0787 mL	5.3933 mL	10.7866 mL	26.9664 mL
	5 mM	0.2157 mL	1.0787 mL	2.1573 mL	5.3933 mL
	10 mM	0.1079 mL	0.5393 mL	1.0787 mL	2.6966 mL
	15 mM	0.0719 mL	0.3596 mL	0.7191 mL	1.7978 mL
	20 mM	0.0539 mL	0.2697 mL	0.5393 mL	1.3483 mL
	25 mM	0.0431 mL	0.2157 mL	0.4315 mL	1.0787 mL
	30 mM	0.0360 mL	0.1798 mL	0.3596 mL	0.8989 mL
	40 mM	0.0270 mL	0.1348 mL	0.2697 mL	0.6742 mL
	50 mM	0.0216 mL	0.1079 mL	0.2157 mL	0.5393 mL
	60 mM	0.0180 mL	0.0899 mL	0.1798 mL	0.4494 mL
	80 mM	0.0135 mL	0.0674 mL	0.1348 mL	0.3371 mL
	100 mM	0.0108 mL	0.0539 mL	0.1079 mL	0.2697 mL

Keywords

Araloside A

2 Cited Publications

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Araloside A

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Publications Citing Use of MedChemExpress (MCE) Araloside A

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Araloside A Related Classifications

HY-N2115 Related Classifications