89013-69-4
Chemical Structure
Theasinensin C
- CAS No.: 89013-69-4
- Formula:C30H26O14
- Molecular Weight:610.52
InChIKey: JPBGHWKYWUEIOT-XYTTVBAYSA-N
SMILES: OC1=CC(O[C@@H]([C@@H](C2)O)C3=C(C4=C([C@H]5OC6=C(C[C@H]5O)C(O)=CC(O)=C6)C=C(O)C(O)=C4O)C(O)=C(O)C(O)=C3)=C2C(O)=C1
Biological Activity: Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila-mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet[1][2].
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Theasinensin C | Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila-mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet. | |||||||||||||||||||||
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- [1]. Li F, et al. Tea polyphenols as novel and potent inhibitory substances against renin activity. J Agric Food Chem. 2013;61(40):9697-9704. [Content Brief]
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[2]. Ji W, et al. Theasinensin C Mitigates HFrD-Induced Neuroinflammation by Enriching Akkermansia muciniphila and Orchestrating a Gln/Ser-Centered Multiorgan Metabolic Relay to Drive Creatine Biosynthesis. J Agric Food Chem. 2026 Apr 1;74(12):10281-10301.
[Content Brief]
Keywords
