Renin
Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.
Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.
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Renin Related Products (78)
Related Products (78)
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Ditekiren
0 ImagesCat. No.: HY-106113CAS No.: 103336-05-6Synonyms: U 71038Ditekiren (U 71038) is a pseudohexapeptide renin inhibitor. Renin is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of renin, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction.
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U-80125
0 ImagesCat. No.: HY-177329CAS No.: 123300-09-4U80215, a dansylated peptide, is a competitive human renin inhibitor with the IC50 of 2.3 μM. U80215 shows excitation and emission maxima at 340 and 530 nm.
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Aliskiren-d6-1 hemifumarate
0 ImagesCat. No.: HY-12176S2Synonyms: CGP 60536-d6 hemifumarate; CGP60536B-d6 hemifumarate; SPP 100-d6 hemifumarateAliskiren-d6-1 hemifumarate (CGP 60536-d6-1 hemifumarate) is the deuterium labeled Aliskiren hemifumarate (HY-12177). Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
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MK-8141
0 ImagesCat. No.: HY-12172CAS No.: 903579-36-2Synonyms: ACT-077825MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.
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Renin-IN-3
0 ImagesCat. No.: HY-177292CAS No.: 911113-39-8Renin-IN-3 (Example 10) is a Renin inhibitor. Renin-IN-3 can be sued for hypertension research.
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PD 132002
0 ImagesCat. No.: HY-129695CAS No.: 134452-04-3PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure.
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CP 71362
0 ImagesCat. No.: HY-182301CAS No.: 112227-15-3CP 71362 is a renin inhibitor, a highly potent substrate-analog transition state mimic with antihypertensive properties. CP 71362 exhibits significant inhibitory activity against plasma renin from rats, dogs, and humans (IC50 values are 3 nM, 0.0033 nM, and 20 nM, respectively). CP 71362 reduces the mean arterial pressure of anesthetized and conscious sodium-depleted animals in a dose-dependent manner, and has pharmacokinetic characteristics of rapid elimination and short duration of action. CP 71362 can be used in research related to hypertension and congestive heart failure.
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Bucumolol
0 ImagesCat. No.: HY-184751CAS No.: 58409-59-9Bucumolol is an orally active β-adrenergic receptor blocker. Bucumolol inhibits Renin release. Bucumolol exhibits activities including local anesthesia, antiarrhythmia, antihypertension, heart rate reduction, negative inotropy, cardiac action potential inhibition, and action potential duration shortening. Bucumolol does not increase cardiac electrical threshold, prolong atrial refractory period, or affect body weight in rodents. Bucumolol can be used in research related to arrhythmia and hypertension.
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CP-69799
0 ImagesCat. No.: HY-P1609CAS No.: 105116-61-8CP-69799 is an azahomostatine-containing oligopeptide transition-state analogue inhibitor with a hog renin IC50 of 6e-9 M, human plasma renin IC50 of 3e-7 M and Ki of 0.310 μM, and endothiapepsin Ki of 0.27 μM. CP-69799 binds endothiapepsin’s active site cleft in extended conformation, fills S4 to S3' pockets, displaces native solvent molecules, induces domain rotation, and reduces thermal mobility of endothiapepsin’s flap and helix regions. CP-69799 acts as a transition-state analogue inhibitor of hog renin and human plasma renin. CP-69799 contains a polar lysine residue at the P2' position, with a nitrogen atom replacing the P1' Cα atom of the hydroxyethylene dipeptide isostere. CP-69799 can be used for the research of hypertension.
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A-74273
0 ImagesCat. No.: HY-129412CAS No.: 130316-95-9A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension.
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Renin inhibitor-1
0 ImagesCat. No.: HY-150963CAS No.: 1093082-54-2Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases.
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Handle region peptide, rat
0 ImagesCat. No.: HY-P1572CAS No.: 749227-53-0Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
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PD 125967
0 ImagesCat. No.: HY-120455CAS No.: 128139-14-0PD 125967 is an oligopeptide renin inhibitor. PD 125967 can be used to low blood pressure.
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Remikiren
0 ImagesCat. No.: HY-A0184CAS No.: 126222-34-2Synonyms: Ro 42-5892; Ro 42-5892/001Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension.
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U 70714E
0 ImagesCat. No.: HY-P1696CAS No.: 114376-16-8U 70714E is a Renin inhibitor with an IC50 of 3.0 nM. U 70714E is used for the research of renin-related hypertension.
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U 77436
0 ImagesCat. No.: HY-P2074CAS No.: 128657-36-3U 77436 is a Renin inhibitory peptide. U 77436 is used in the research of hypertension.
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Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
0 ImagesCat. No.: HY-P5976CAS No.: 76524-84-0Synonyms: Renin Substrate I
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Aliskiren (Standard)
0 ImagesSynonyms: CGP 60536 (Standard); CGP60536B (Standard); SPP 100 (Standard)Aliskiren (Standard) is the analytical standard of Aliskiren. This product is intended for research and analytical applications. Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
