58409-59-9
Chemical Structure
Bucumolol
- CAS No.: 58409-59-9
- Formula:C17H23NO4
- Molecular Weight:305.37
InChIKey: CIJVBYRUFLGDHY-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C=CC(C)=C2C=C1)OCC(CNC(C)(C)C)O
Biological Activity: Bucumolol is an orally active β-adrenergic receptor blocker. Bucumolol inhibits Renin release. Bucumolol exhibits activities including local anesthesia, antiarrhythmia, antihypertension, heart rate reduction, negative inotropy, cardiac action potential inhibition, and action potential duration shortening. Bucumolol does not increase cardiac electrical threshold, prolong atrial refractory period, or affect body weight in rodents. Bucumolol can be used in research related to arrhythmia and hypertension[1][2][3].
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Bucumolol | Bucumolol is an orally active β-adrenergic receptor blocker. Bucumolol inhibits Renin release. Bucumolol exhibits activities including local anesthesia, antiarrhythmia, antihypertension, heart rate reduction, negative inotropy, cardiac action potential inhibition, and action potential duration shortening. Bucumolol does not increase cardiac electrical threshold, prolong atrial refractory period, or affect body weight in rodents. Bucumolol can be used in research related to arrhythmia and hypertension. | |||||||||||||||||||||
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- [1]. Nakayama K, et al. Antiarrhythmic activity of dextro- and levo-isomers of 5-methyl-8-(2-hydroxy-3-t-butylamino-propoxy) coumarin hydrocholoride (bucumolol), a beta-adrenergic blocking agent, on aconitine-induced atrial and ouabain-induced ventricular arrhythmias in dogs. Jpn J Pharmacol. 1979 Dec;29(6):935-45. [Content Brief]
- [2]. Miyamoto M, et al. Antihypertensive activity of bucumolol, a beta-adrenergic blocking agent, in spontaneously hypertensive rats. Journal of pharmacobio-dynamics. 1981 Jul;4(7):455-60.
- [3]. Ichiyama M, et al. Effects of bucumolol, nadolol and nifenalol on maximum upstroke velocity of action potential in guinea pig papillary muscles. Naunyn-Schmiedeberg's archives of pharmacology. 1986 Mar;332(3):297-304.
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