Bucumolol
Bucumolol is an orally active β-adrenergic receptor blocker. Bucumolol inhibits Renin release. Bucumolol exhibits activities including local anesthesia, antiarrhythmia, antihypertension, heart rate reduction, negative inotropy, cardiac action potential inhibition, and action potential duration shortening. Bucumolol does not increase cardiac electrical threshold, prolong atrial refractory period, or affect body weight in rodents. Bucumolol can be used in research related to arrhythmia and hypertension.
For research use only. We do not sell to patients.
- CAS No.: 58409-59-9
- Formula: C17H23NO4
- Molecular Weight:305.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
Bucumolol potently induces a concentration-dependent negative inotropic effect in isolated guinea pig left atrial muscles, with a log 1/ED40 value of 0.097 mM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Bucumolol (50 mg/kg; p.o.; once daily; 6 weeks) suppresses hypertension development, lowers heart rate, and reduces plasma renin concentration in 5-week-old male spontaneously hypertensive rats, with no significant effect on body weight or plasma aldosterone concentration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SHR (male, 15 weeks of age)[2]
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Dosage:50 mg/kg
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Administration:p.o.; single dose
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Result:Decreased mean blood pressure from 163.8 mmHg to 149.4 mmHg (8.4% reduction, p < 0.01, N=8).
Lowered heart rate from 343.8 beats/min to 303.8 beats/min (p < 0.01, N=8).
Reduced plasma renin concentration from 4.23 ng/mL/h to 2.53 ng/mL/h (43.7% reduction, p < 0.01, N=8).
Showed a significant positive correlation (r=0.716, p < 0.05) between percent changes in plasma renin concentration and mean blood pressure.
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Animal Model:SHR (male, 5 weeks of age)[2]
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Dosage:50 mg/kg
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Administration:p.o.; once daily; 6 weeks
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Result:Produced significantly lower systolic blood pressure compared to controls as early as 1 week after dosing, with the difference sustained for 6 weeks.
Lowered heart rate throughout the 6-week period.
Reduced plasma renin concentration to 1.9 ng/mL/h (p < 0.05, final N=6) compared to control 4.4 ng/mL/h.
Tended to lower plasma aldosterone concentration to 226.8 pg/mL, with no statistically significant difference relative to control 304.4 pg/mL.
Showed no statistically significant difference in body weight compared to controls.
Chemical Information
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CAS No. 58409-59-9
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Molecular Weight 305.37
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Formula C17H23NO4
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SMILES
O=C1OC2=C(C=CC(C)=C2C=C1)OCC(CNC(C)(C)C)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nakayama K, et al. Antiarrhythmic activity of dextro- and levo-isomers of 5-methyl-8-(2-hydroxy-3-t-butylamino-propoxy) coumarin hydrocholoride (bucumolol), a beta-adrenergic blocking agent, on aconitine-induced atrial and ouabain-induced ventricular arrhythmias in dogs. Jpn J Pharmacol. 1979 Dec;29(6):935-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bucumolol Related Classifications
HY-184751 Related Classifications
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- Bucumolol
- 58409-59-9
- Adrenergic Receptor
- Renin
- ouabain-induced ventricular arrhythmia
- spontaneously hypertensive rats
- cardiac fast sodium channel
- guinea pig papillary muscles
- guinea-pig right atria
- aconitine-induced atrial arrhythmia
- frog sciatic nerves
- guinea pig left atrial muscles
- β-adrenergic receptor
- hypertensive rodents
- Inhibitor
- inhibitor
- inhibit