130316-95-9
Chemical Structure
A-74273
- CAS No.: 130316-95-9
- Formula:C44H74N4O8
- Molecular Weight:787.08
IUPAC Name: (2S)-6-cyclohexyl-4-hydroxy-2-isopropyl-5-((S)-2-(((S)-1-(4-(methoxymethoxy)piperidin-1-yl)-1-oxo-3-phenylpropan-2-yl)oxy)hexanamido)-N-(3-morpholinopropyl)hexanamide
InChIKey: NVMVSIUABPBQIL-NYURHMAOSA-N
SMILES: CCCC[C@H](O[C@H](C(N1CCC(OCOC)CC1)=O)CC2=CC=CC=C2)C(NC(C(O)C[C@H](C(NCCCN3CCOCC3)=O)C(C)C)CC4CCCCC4)=O
Biological Activity: A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension[1][2].
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A-74273 | A-74273 is an orally active peptide renin inhibitor (IC50=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension. | |||||||||||||||||||||
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References
- [1]. Dayton, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clinical chemistry 38.11 (1992): 2239-2243. [Content Brief]
- [2]. Kleinert, et al. "Discovery of a well-absorbed, efficacious renin inhibitor, A-74273." Hypertension 20.6 (1992): 768-775. [Content Brief]
