Aliskiren-d₆ (hemifumarate) (Synonyms: CGP 60536 d₆ (hemifumarate); CGP60536B d₆ (hemifumarate); SPP 100 d₆ (hemifumarate))

Cat. No.: HY-12177S: FAQs
Data Sheet Handling Instructions

Aliskiren-d₆ (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].

For research use only. We do not sell to patients.

Aliskiren-d<sub>6</sub> (hemifumarate) Chemical Structure

Aliskiren-d₆ (hemifumarate) Chemical Structure

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of Aliskiren-d₆ (hemifumarate):

Biological Activity
Purity & Documentation
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Customer Review

Description	Aliskiren-d₆ (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM[1][2].
IC₅₀ & Target	IC50: 1.5 nM (renin)^[1]
Molecular Weight	615.83
Formula	C₃₂H₄₉D₆N₃O₈
SMILES	O=C(NCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C(N)=O)[[email protected]](C(C)C)C[[email protected]](O)[[email protected]@H](N)C[[email protected]@H](C(C)C)CC1=CC(OCCCOC)=C(OC)C=C1.O=C(O)/C=C/C(O)=O.[1/2]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Yuji Nakamura, et al. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med. Chem. Lett., 2012, 3 (9), pp 754-758. [Content Brief] [2]. Buczko W, et al. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Aliskiren-d₆ (hemifumarate)CGP 60536 d₆ hemifumarateCGP60536B d₆ hemifumarateSPP 100 d₆ hemifumarateReninAutophagyDeuteriumlabeledorallyactiveInhibitorinhibitorinhibit

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Aliskiren-d6 (hemifumarate) (Synonyms: CGP 60536 d6 (hemifumarate); CGP60536B d6 (hemifumarate); SPP 100 d6 (hemifumarate))

Other Forms of Aliskiren-d6 (hemifumarate):

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator