2. Metabolic Enzyme/Protease
  3. Renin
  4. Renin inhibitor-1

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases.

For research use only. We do not sell to patients.

Renin inhibitor-1 Chemical Structure

Renin inhibitor-1 Chemical Structure

CAS No. : 1093082-54-2

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Renin inhibitor-1 Related Antibodies

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Description

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].

IC50 & Target

IC50: 0.9 nM (rh-renin); 1.8 nM (hPRA)[1]
In Vivo

Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

414.50

Formula

C22H30N4O4
CAS No.
SMILES

O=C(OC)NCCCN1C=C(CN(C2CC2)C([C@H]3CNCCO3)=O)C4=C1C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Renin inhibitor-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Renin inhibitor-11093082-54-2Renin inhibitor1Renin inhibitor 1Reninorally activeantihypertensivetsukuba hypertensive miceInhibitorinhibitorinhibit

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