126222-34-2
Chemical Structure
Remikiren
Synonym(s): Ro 42-5892; Ro 42-5892/001
- CAS No.: 126222-34-2
- Formula:C33H50N4O6S
- Molecular Weight:630.84
IUPAC Name: (S)-2-benzyl-3-(tert-butylsulfonyl)-N-((S)-1-(((2S,3R,4S)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl)amino)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)propanamide
InChIKey: UXIGZRQVLGFTOU-VQXQMPIVSA-N
SMILES: CC(C)(C)S(C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CN=CN2)C(N[C@H]([C@@H](O)[C@H](C3CC3)O)CC4CCCCC4)=O)=O)(=O)=O
Biological Activity: Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Remikiren | Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
