112227-15-3
Chemical Structure
CP 71362
- CAS No.: 112227-15-3
- Formula:C51H76N8O9
- Molecular Weight:945.20
InChIKey: YHLJEWZZOJLRNJ-CJAFUUPZSA-N
SMILES: O=C([C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1)N[C@H](C(N[C@@]([H])(CC2CCCCC2)[C@@H](O)C[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CCCCN)=O)CC(C)C)=O)CC4=CNC=N4
Biological Activity: CP 71362 is a renin inhibitor, a highly potent substrate-analog transition state mimic with antihypertensive properties. CP 71362 exhibits significant inhibitory activity against plasma renin from rats, dogs, and humans (IC50 values are 3 nM, 0.0033 nM, and 20 nM, respectively). CP 71362 reduces the mean arterial pressure of anesthetized and conscious sodium-depleted animals in a dose-dependent manner, and has pharmacokinetic characteristics of rapid elimination and short duration of action. CP 71362 can be used in research related to hypertension and congestive heart failure[1][2].
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CP 71362 | CP 71362 is a renin inhibitor, a highly potent substrate-analog transition state mimic with antihypertensive properties. CP 71362 exhibits significant inhibitory activity against plasma renin from rats, dogs, and humans (IC50 values are 3 nM, 0.0033 nM, and 20 nM, respectively). CP 71362 reduces the mean arterial pressure of anesthetized and conscious sodium-depleted animals in a dose-dependent manner, and has pharmacokinetic characteristics of rapid elimination and short duration of action. CP 71362 can be used in research related to hypertension and congestive heart failure. | |||||||||||||||||||||
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- [1]. Kleinman E F, et al. CP-71,362, an unusually potent inhibitor of rat and dog renin[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4(4): 589-592.
- [2]. Mangiapane ML, et al. CP-71,362: a pentapeptide renin inhibitor selective for the canine enzyme. Clin Exp Hypertens. 1994;16(4):507-533. [Content Brief]
Keywords
