Renin
Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.
Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.
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Renin Related Products (78)
Related Products (78)
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SR 43845
0 ImagesCat. No.: HY-105259CAS No.: 114037-60-4SR 43845 is a renin inhibitor. SR 43845 decreases blood pressure and inhibits plasma renin activity. SR 43845 can be used for hypertension research.
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PD-134672
0 ImagesCat. No.: HY-19145CAS No.: 135704-06-2Synonyms: CI-992PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.
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KRI-1177
0 ImagesCat. No.: HY-119036CAS No.: 105186-68-3KRI-1177 is a competitive, dipeptide human renin inhibitor with a Ki of 0.7 μM and an IC50 of 90 nM. The IC50 of KRI-1177 targeting cynomolgus monkey renin is 680 nM. KRI-1177 acts as an antihypertensive agent, angiotensin inhibitor and plasma renin activity inhibitor, which reduces systemic blood pressure and plasma angiotensin concentration. KRI-1177 exhibits a relatively long-lasting antihypertensive effect in cynomolgus monkeys and can be used for hypertension research.
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WJM590
0 ImagesCat. No.: HY-187367WJM590 is an orally active antimalarial agent that also exhibits inhibitory activities against renin, cathepsin D, BACE1, and plasmodial aspartic proteases. WJM590 inhibits substrate and protein maturation processing mediated by key proteases of Plasmodium falciparum, arrests asexual blood-stage parasites at the late schizont stage, inhibits merozoite release, and blocks malaria parasite transmission via vectors. WJM590 exerts selective inhibitory activity against multiple Plasmodium species and drug-resistant Plasmodium falciparum strains, and reduces parasitemia in infected mice. WJM590 can be used in malaria-related research.
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EMD 52297
0 ImagesCat. No.: HY-129714CAS No.: 129049-51-0EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor.
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Renin inhibitory peptide, statine
0 ImagesCat. No.: HY-P2637CAS No.: 94162-23-9Renin inhibitory peptide, statine is an inhibitor of Renin. Renin inhibitory peptide, statine inhibits the plasma renin activity of human plasma renin, porcine renin, and sodium-depleted conscious dogs. Renin inhibitory peptide, statine reduces the mean arterial pressure of sodium-depleted conscious dogs, induces a sustained, dose-dependent decrease in blood pressure, and triggers a maximum hypotensive response. Renin inhibitory peptide, statine can be used in hypertension-related research.
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A-65317
0 ImagesCat. No.: HY-129607CAS No.: 122224-84-4A-65317 is a primate-selective renin dipeptide inhibitor (IC50 of 0.37 nM) with long hypotensive response.
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PD125754
0 ImagesCat. No.: HY-120756CAS No.: 124339-32-8PD125754 is an oligopeptide renin inhibitor (IC50: 22 nM).
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KRI-1314
0 ImagesCat. No.: HY-183978CAS No.: 128053-53-2KRI-1314 is an orally active human renin inhibitor with selectivity for primate renin over non-primate renin. KRI-1314 competitively inhibits the binding of recombinant human renin to its substrate, reduces plasma renin activity, lowers blood pressure, and exhibits high stability in tissue homogenates. KRI-1314 is applicable to research on renin-dependent hypertension and hypertension-related studies.
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H256
0 ImagesCat. No.: HY-P1608CAS No.: 100111-08-8H256 is an inhibitor of Endothiapepsin and Pepsin, with a Ki value of 60 nM against Endothiapepsin.
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CGS 13928C
0 ImagesCat. No.: HY-105978CAS No.: 83348-78-1Synonyms: Wy-44655CGS 13928C (Wy-44655) is an angiotensin-converting enzyme (ACE) inhibitor. CGS 13928C effectively inhibits the pressor and blood pressure responses induced by exogenous angiotensin I by blocking the renin-angiotensin system. CGS 13928C exhibits dose-dependent hypotensive activity.
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ES-8891
0 ImagesCat. No.: HY-117913CAS No.: 129445-88-1ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis.
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SC-46944
0 ImagesCat. No.: HY-120586CAS No.: 120729-15-9SC-46944 is an orally active renin inhibitor and can be used for study of hypertension.
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ES 6864
0 ImagesCat. No.: HY-125625CAS No.: 116326-39-7ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets.
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Aliskiren hemifumarate (Standard)
0 ImagesSynonyms: CGP 60536 hemifumarate (Standard); CGP60536B hemifumarate (Standard); SPP 100 hemifumarate (Standard)Aliskiren (hemifumarate) (Standard) is the analytical standard of Aliskiren (hemifumarate). This product is intended for research and analytical applications. Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia.
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Araloside A (Standard)
0 ImagesAraloside A (Standard) (Chikusetsusaponin IV (Standard)), triterpenoid saponins, is an orally active component of Aralia elata. Araloside A (Standard) shows low-renin-inhibitory activity with an IC50 of 77.4 μM. Araloside A (Standard) can inhibit cell proliferation and induce apoptosis. Araloside A (Standard) suppresses inflammatory cytokines IL-1β and IL-6 production. Araloside A (Standard) can be used for the researches of cancer, inflammation and cardiovascular disease, such as renal cell carcinoma and rheumatoid arthritis.
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ACT 178882
0 ImagesCat. No.: HY-U00262CAS No.: 1007392-69-9ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.
