129049-51-0
129049-51-0
Chemical Structure
EMD 52297
- CAS No.: 129049-51-0
- Formula:C39H59N11O7
- Molecular Weight:793.96
IUPAC Name: tert-butyl (12-((1H-imidazol-5-yl)methyl)-4-(sec-butyl)-9-(cyclohexylmethyl)-8-hydroxy-3,6,11,14-tetraoxo-16-phenyl-1-(2H-tetrazol-2-yl)-2,5,10,13-tetraazahexadecan-15-yl)carbamate
InChIKey: LXFRBEWNYDBACO-UHFFFAOYSA-N
SMILES: O=C(NC(CC1=CC=CC=C1)C(NC(CC2=CN=CN2)C(NC(C(CC(NC(C(CC)C)C(NCN3N=NC=N3)=O)=O)O)CC4CCCCC4)=O)=O)OC(C)(C)C
Biological Activity: EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor[1][2].
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EMD 52297 | EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor. | |||||||||||||||||||||
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References
- [1]. Miriam T Rademaker, et al. Hemodynamic, hormonal, and renal effects of (pro)renin receptor blockade in experimental heart failure. Circ Heart Fail. 2012 Sep 1;5(5):645-52. [Content Brief]
- [2]. Jürgen Maibaum, et al. Renin inhibitors as novel treatments for cardiovascular disease. Expert Opinion on Therapeutic Patents. Volume 13, 2003 - Issue 5.
Keywords
