83348-78-1
83348-78-1
Chemical Structure
CGS 13928C
Synonym(s): Wy-44655
- CAS No.: 83348-78-1
- Formula:C24H27N2NaO5
- Molecular Weight:446.47
IUPAC Name: (S)-1-(((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl)indoline-2-carboxylic acid, sodium salt
InChIKey: XPOXELABJLPBTQ-FMCJTSGUSA-M
SMILES: CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N2C3=CC=CC=C3C[C@H]2C(O[Na])=O)=O)=O
Biological Activity: CGS 13928C (Wy-44655) is an angiotensin-converting enzyme (ACE) inhibitor. CGS 13928C effectively inhibits the pressor and blood pressure responses induced by exogenous angiotensin I by blocking the renin-angiotensin system. CGS 13928C exhibits dose-dependent hypotensive activity[1][2].
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CGS 13928C | CGS 13928C (Wy-44655) is an angiotensin-converting enzyme (ACE) inhibitor. CGS 13928C effectively inhibits the pressor and blood pressure responses induced by exogenous angiotensin I by blocking the renin-angiotensin system. CGS 13928C exhibits dose-dependent hypotensive activity. | |||||||||||||||||||||
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References
- [1]. Buchwalder-Csajka C, et al.. Evaluation of the angiotensin challenge methodology for assessing the pharmacodynamic profile of antihypertensive drugs acting on the renin-angiotensin system. British journal of clinical pharmacology. 1999 Oct;48(4):594-604. [Content Brief]
- [2]. Schaller M D, Brunner D B, Nussberger J, et al. A potent converting enzyme inhibitor CGS 13928C. Drug profile in normal volunteers[J]. European journal of clinical pharmacology, 1984, 26(4): 419-424.
