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Cat. No.: HY-P1608

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H256

H256 is an inhibitor of Endothiapepsin and Pepsin, with a K_i value of 60 nM against Endothiapepsin.

For research use only. We do not sell to patients.

CAS No.: 100111-08-8
Formula: C₄₃H₆₂N₁₀O₁₂
Molecular Weight:911.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H256 Chemical Structure

CAS No.: 100111-08-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

H256 is an inhibitor of Endothiapepsin and Pepsin, with a K_i value of 60 nM against Endothiapepsin^[1]^[2].

In Vitro

H256 exhibits relatively weak inhibitory activity against h-Renin (K_i > 7600 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 100111-08-8
Molecular Weight 911.01
Formula C₄₃H₆₂N₁₀O₁₂
SMILES

O=C(O)CC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)NC[C@@H](NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H]2NCCC2)=O)=O)=O)CC3=CC=CC=C3)=O)=O
Sequence

Pro-Thr-Glu-Phe-Phe-Arg-Glu
Sequence Shortening

PTEFFRE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cooper J, et al. The structure of a synthetic pepsin inhibitor complexed with endothiapepsin. Eur J Biochem. 1987 Nov 16;169(1):215-21.

[2]. Guruprasad K, et al. Comparative modelling of barley-grain aspartic proteinase: a structural rationale for observed hydrolytic specificity. FEBS Lett. 1994 Sep 26;352(2):131-6.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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