94162-23-9
Chemical Structure
Renin inhibitory peptide, statine
- CAS No.: 94162-23-9
- Formula:C54H77N13O9
- Molecular Weight:1052.27
IUPAC Name: N-(1-((1-((1-((1-((1-amino-1-oxo-3-phenylpropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl)amino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-1-((2-amino-2-methylbutanoyl)histidyl)pyrrolidine-2-carboxamide
InChIKey: MLPPVPSNEAYJAT-IDSKXIRVSA-N
SMILES: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H]([C@@H](C)CC)N(C([C@H](CC2=CNC=N2)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CC5=CNC=N5)NC([C@@](C)(CC)N)=O)=O)CCC4)=O)=O)=O)C(C[C@H](O)[C@@H](N)CC(C)C)=O)=O
Biological Activity: Renin inhibitory peptide, statine is an inhibitor of Renin. Renin inhibitory peptide, statine inhibits the plasma renin activity of human plasma renin, porcine renin, and sodium-depleted conscious dogs. Renin inhibitory peptide, statine reduces the mean arterial pressure of sodium-depleted conscious dogs, induces a sustained, dose-dependent decrease in blood pressure, and triggers a maximum hypotensive response. Renin inhibitory peptide, statine can be used in hypertension-related research[1][2].
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Renin inhibitory peptide, statine | Renin inhibitory peptide, statine is an inhibitor of Renin. Renin inhibitory peptide, statine inhibits the plasma renin activity of human plasma renin, porcine renin, and sodium-depleted conscious dogs. Renin inhibitory peptide, statine reduces the mean arterial pressure of sodium-depleted conscious dogs, induces a sustained, dose-dependent decrease in blood pressure, and triggers a maximum hypotensive response. Renin inhibitory peptide, statine can be used in hypertension-related research. | |||||||||||||||||||||
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- [1]. Blaine EH, et al. Statine-containing renin inhibitor. Dissociation of blood pressure lowering and renin inhibition in sodium-deficient dogs. Hypertension (Dallas, Tex. : 1979). 1984;6(2 Pt 2):I111-8.
- [2]. Blaine EH, et al. Characteristics of the blood pressure lowering action of renin inhibition and comparison with angiotensin converting enzyme inhibition. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 1989 Apr;7(2):S47-9.
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