Aliskiren-d₆-1 hemifumarate  (Synonyms: CGP 60536-d₆ hemifumarate; CGP60536B-d₆ hemifumarate; SPP 100-d₆ hemifumarate)

Aliskiren-d₆-1 hemifumarate (CGP 60536-d₆-1 hemifumarate) is the deuterium labeled Aliskiren hemifumarate (HY-12177). Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC₅₀ of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia^[1][2][3].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

673.87

C₃₄H₅₁D₆N₃O₁₀

173334-57-1

CC(C)[C@@H](CC1=CC=C(OC)C(OCCCOC)=C1)C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(NCC(C([2H])([2H])[2H])(C(N)=O)C([2H])([2H])[2H])=O.O=C(O)/C=C/C(O)=O.[1/2]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.