1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Aldosterone

Aldosterone 

Cat. No.: HY-113313 Purity: >99.0%
Handling Instructions

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level.

For research use only. We do not sell to patients.

Aldosterone Chemical Structure

Aldosterone Chemical Structure

CAS No. : 52-39-1

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10 mM * 1 mL in DMSO USD 337 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4].
Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male Wistar rats[4]
Dosage: 1 mg/Kg (+1% NaCl)
Administration: i.h.; once daily for 3 weeks
Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.
Clinical Trial
Molecular Weight

360.44

Formula

C₂₁H₂₈O₅

CAS No.

52-39-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: >99.0%

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Keywords:

AldosteroneEndogenous Metabolitemineralocorticoidsteroidhormonerenin-angiotensinsystemactivationzonaglomerulosareceptorInhibitorinhibitorinhibit

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Aldosterone
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HY-113313
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