Torsemide-d7
Based on 1 Customer Validation
Torsemide-d7 is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis.
For research use only. We do not sell to patients.
- CAS No.: 1189375-06-1
- Formula: C16H13D7N4O3S
- Molecular Weight:355.46
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1189375-06-1
-
Unlabeled Cas 56211-40-6
-
Appearance Solid
-
Molecular Weight 355.46
-
Formula C16H13D7N4O3S
-
Color White to off-white
-
SMILES
CC1=CC(NC2=CC=NC=C2S(NC(NC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)(=O)=O)=CC=C1
-
Synonyms
Torasemide-d7
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (70.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Ishido, H., et al. Torasemide for the Treatment of Heart Failure. Cardiovascular & Hematological Disorders-Drug Targets. 2008. 8(2), 127–132. [Content Brief]
[3]. Goodfriend, T. L., et al. Torsemide inhibits aldosterone secretion in vitro. Life Sciences. 1998. 63(3), PL45–PL50. [Content Brief]
[4]. H A Friedel, et al. Torasemide. A review of its pharmacological properties and therapeutic potential. Drugs. 1991 Jan;41(1):81-103. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8133 mL | 14.0663 mL | 28.1326 mL | 70.3314 mL |
| 5 mM | 0.5627 mL | 2.8133 mL | 5.6265 mL | 14.0663 mL | |
| 10 mM | 0.2813 mL | 1.4066 mL | 2.8133 mL | 7.0331 mL | |
| 15 mM | 0.1876 mL | 0.9378 mL | 1.8755 mL | 4.6888 mL | |
| 20 mM | 0.1407 mL | 0.7033 mL | 1.4066 mL | 3.5166 mL | |
| 25 mM | 0.1125 mL | 0.5627 mL | 1.1253 mL | 2.8133 mL | |
| 30 mM | 0.0938 mL | 0.4689 mL | 0.9378 mL | 2.3444 mL | |
| 40 mM | 0.0703 mL | 0.3517 mL | 0.7033 mL | 1.7583 mL | |
| 50 mM | 0.0563 mL | 0.2813 mL | 0.5627 mL | 1.4066 mL | |
| 60 mM | 0.0469 mL | 0.2344 mL | 0.4689 mL | 1.1722 mL |
Torsemide-d7 Related Classifications
HY-B0247S Related Classifications
Powered by Bioz