10(11)-Cl-BBQ
10 (11)-Cl-BBQ is a high-affinity aryl hydrocarbon receptor (AhR) agonist. 10 (11)-Cl-BBQ is a mixture of 10-Cl-BBQ and 11-Cl-BBQ, among which 11-Cl-BBQ exhibits higher AhR activation potency than 10-Cl-BBQ. Low-dose/short-term AhR activation by 10 (11)-Cl-BBQ promotes IL-17 production, while high-dose/sustained activation induces regulatory T cells and suppresses immune responses. 10 (11)-Cl-BBQ can be used in immunomodulation research.
For research use only. We do not sell to patients.
- Formula: C19H13ClN2O
- Molecular Weight:304.73
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
IL-17 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (B6) (female, 9-12 weeks of age)[1]
-
Dosage:10 mg/kg
-
Administration:i.p.; single dose
-
Result:Induced hepatic Cyp1a1 expression at a level lower than that induced by 11-Cl-BBQ at 10 mg/kg.
Chemical Information
-
Molecular Weight 304.73
-
Formula C19H13ClN2O
-
SMILES
ClC1=CC2=C(C=C1)N=C(N32)C4=C5C(C=CC=C5C3=O)=CC=C4.O=C(N6C(C=C7)=C(N=C68)C=C7Cl)C9=C%10C8=CC=CC%10=CC=C9
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz