2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor Interleukin Related
  4. 10(11)-Cl-BBQ

10 (11)-Cl-BBQ is a high-affinity aryl hydrocarbon receptor (AhR) agonist. 10 (11)-Cl-BBQ is a mixture of 10-Cl-BBQ and 11-Cl-BBQ, among which 11-Cl-BBQ exhibits higher AhR activation potency than 10-Cl-BBQ. Low-dose/short-term AhR activation by 10 (11)-Cl-BBQ promotes IL-17 production, while high-dose/sustained activation induces regulatory T cells and suppresses immune responses. 10 (11)-Cl-BBQ can be used in immunomodulation research.

For research use only. We do not sell to patients.

10(11)-Cl-BBQ

10(11)-Cl-BBQ Chemical Structure

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10(11)-Cl-BBQ Related Antibodies

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Description

10 (11)-Cl-BBQ is a high-affinity aryl hydrocarbon receptor (AhR) agonist. 10 (11)-Cl-BBQ is a mixture of 10-Cl-BBQ and 11-Cl-BBQ, among which 11-Cl-BBQ exhibits higher AhR activation potency than 10-Cl-BBQ. Low-dose/short-term AhR activation by 10 (11)-Cl-BBQ promotes IL-17 production, while high-dose/sustained activation induces regulatory T cells and suppresses immune responses. 10 (11)-Cl-BBQ can be used in immunomodulation research[1].

IC50 & Target[1]

IL-17

 

In Vivo

10(11)-Cl-BBQ (10 mg/kg; i.p.; single dose) induces hepatic Cyp1a1 expression in healthy mice at 20 h, with lower potency than 11-Cl-BBQ at the same dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (B6) (female, 9-12 weeks of age)[1]
Dosage: 10 mg/kg
Administration: i.p.; single dose
Result: Induced hepatic Cyp1a1 expression at a level lower than that induced by 11-Cl-BBQ at 10 mg/kg.
Molecular Weight

304.73

Formula

C19H13ClN2O
SMILES

ClC1=CC2=C(C=C1)N=C(N32)C4=C5C(C=CC=C5C3=O)=CC=C4.O=C(N6C(C=C7)=C(N=C68)C=C7Cl)C9=C%10C8=CC=CC%10=CC=C9
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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10(11)-Cl-BBQ Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10(11)-Cl-BBQAryl Hydrocarbon ReceptorInterleukin RelatedAhRILB cellCyp1a1CD4+ T cellshealthy miceAhR pathwayFoxp3- Tr1 cellsaryl hydrocarbon receptorFoxp3+ regulatory T cellsIL-17Inhibitorinhibitorinhibit

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