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ITE Chemical Structure
|Product name: ITE|
|Cat. No.: HY-19317|
ITE is a aryl hydrocarbon receptor (AhR) agonist with Ki of 3 nM, and the estimated IC50 of ITE for OVCAR-3 cell proliferation was 0.2 nM.
IC50 value: 0.2?nM (for OVCAR-3 cell), 3 nM (Ki) 
in vitro: ITE is the endogenous high-affinity AhR agonist, possesses potent anticancer activity but the mechanism of action remains unclear. ITE enhances the binding of the AhR to the promoter of Oct4 and suppresses its transcription. ITE is presumably high enough in exerting its biological functions. 
in vivo: ITE is a potential compound to induce functional FoxP3+ Treg in vivo and treat autoimmune diseases.
|M.Wt||286.31||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||3.4927 mL||17.4636 mL||34.9272 mL|
|5 mM||0.6985 mL||3.4927 mL||6.9854 mL|
|10 mM||0.3493 mL||1.7464 mL||3.4927 mL|
. Quintana FJ, et al. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20768-20773.