Dioleyldimethylammonium chloride
Based on 1 Customer Validation
Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 95.88%
- CAS. Nr.: 7212-69-3
- Formel: C38H76ClN
- Molecular Weight:582.47
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Dioleyldimethylammonium (chloride)/DOPE cationic liposomes disrupt BHK cell membrane integrity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PEG-DSPE-based PFVs loaded with Mitoxantrone (HY-13502) and containing Dioleyldimethylammonium chloride (2.0 mg/kg; intravenous injection; administered three times on days 2, 6, and 10) significantly delay the growth of LS180 colon cancer xenografts in SCID/Rag2 mice, with the first palpable tumor detected on day 28; in contrast, the efficacy of PEG-DMPE-based formulations is reduced compared with free Mitoxantrone[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID/Rag2 mice with Colon carcinoma[2]
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Dosage:2.0 mg/kg
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Administration:i.v.; 3 doses on days 2, 6, and 10
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Result:Delayed LS180 colon carcinoma xenograft growth initiation to approximately day 28 for formulation with PEG-DSPE, compared to untreated controls (palpable by day 12) and free mitoxantrone-treated mice (palpable by day 17-18).
Showed reduced efficacy relative to free mitoxantrone for formulation with PEG-DMPE, with tumor growth initiating earlier than the PEG-DSPE PFV group.
Chemical Information
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CAS. Nr. 7212-69-3
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Appearance Solid-Liquid Mixture
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Molecular Weight 582.47
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Formel C38H76ClN
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Color Light yellow to yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCC[N+](C)(C)CCCCCCCC/C=C\CCCCCCCC.[Cl-]
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Synonyms
DODAC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (171.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 100 mg/mL (171.68 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.7168 mL | 8.5841 mL | 17.1683 mL | 42.9207 mL |
| 5 mM | 0.3434 mL | 1.7168 mL | 3.4337 mL | 8.5841 mL | |
| 10 mM | 0.1717 mL | 0.8584 mL | 1.7168 mL | 4.2921 mL | |
| 15 mM | 0.1145 mL | 0.5723 mL | 1.1446 mL | 2.8614 mL | |
| 20 mM | 0.0858 mL | 0.4292 mL | 0.8584 mL | 2.1460 mL | |
| 25 mM | 0.0687 mL | 0.3434 mL | 0.6867 mL | 1.7168 mL | |
| 30 mM | 0.0572 mL | 0.2861 mL | 0.5723 mL | 1.4307 mL | |
| 40 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0730 mL | |
| 50 mM | 0.0343 mL | 0.1717 mL | 0.3434 mL | 0.8584 mL | |
| 60 mM | 0.0286 mL | 0.1431 mL | 0.2861 mL | 0.7153 mL | |
| 80 mM | 0.0215 mL | 0.1073 mL | 0.2146 mL | 0.5365 mL | |
| 100 mM | 0.0172 mL | 0.0858 mL | 0.1717 mL | 0.4292 mL |
Dioleyldimethylammonium chloride Related Classifications
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