7212-69-3
Chemical Structure
Dioleyldimethylammonium chloride
Synonym(s): DODAC
- No. CAS: 7212-69-3
- Formula:C38H76ClN
- Molecular Weight:582.47
IUPAC Name: (Z)-N,N-dimethyl-N-((Z)-octadec-9-en-1-yl)octadec-9-en-1-aminium chloride
InChIKey: UAKOZKUVZRMOFN-JDVCJPALSA-M
SMILES: CCCCCCCC/C=C\CCCCCCCC[N+](C)(C)CCCCCCCC/C=C\CCCCCCCC.[Cl-]
Biological Activity: Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Dioleyldimethylammonium chloride | 95.88% | Dioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer. | ||||||||||||||||||||
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References
- [1]. Lee S Y, et al. Stimulation of phospholipase D in HepG2 cells after transfection using cationic liposomes[J]. Bulletin of the Korean Chemical Society, 2013, 34(3): 931-935.
- [2]. Adlakha-Hutcheon G, et al. Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity. Nat Biotechnol. 1999;17(8):775-779. [Content Brief]
