2. Recombinant Proteins
  3. Enzymes & Regulators Kinases
  4. Transferases (EC 2) Serine/Threonine Kinase Proteins Other Kinases
  5. CAMKK
  6. CaMKK1
  7. CAMKK1 Protein, Rat (F230G, sf9, GST)

CAMKK1 Protein, Rat (F230G, sf9, GST) is the recombinant rat-derived CAMKK1, expressed by Sf9 insect cells , with GST labeled tag.

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CAMKK1 Protein, Rat (F230G, sf9, GST) is the recombinant rat-derived CAMKK1, expressed by Sf9 insect cells , with GST labeled tag.
Background

CAMKK1, a calcium/calmodulin-dependent protein kinase, plays a pivotal role in a proposed calcium-triggered signaling cascade that impacts various cellular processes. This kinase exhibits the ability to phosphorylate CAMK1, CAMK1D, CAMK1G, and CAMK4, suggesting its involvement in regulating multiple downstream effectors. CAMKK1 is particularly implicated in the modulation of cell apoptosis, where it promotes cell survival by phosphorylating AKT1/PKB. This phosphorylation event, in turn, inhibits the pro-apoptotic protein BAD (Bcl2-antagonist of cell death), highlighting the intricate regulatory role of CAMKK1 in cellular survival pathways. It has to underscore CAMKK1's significance in orchestrating calcium-dependent signaling cascades and its impact on the delicate balance between cell survival and apoptosis.
Species

Rat
Source

Sf9 insect cells
Tag

GST
Accession

P97756 (M1-S505)
Gene ID

60341
Protein Length

Full Length
Synonyms
Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha (CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha)
AA Sequence

MERSPAVCCQDPRAELVERVAAISVAHLEEAEEGPEPASNGVDPPPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLEAQVGPYSTGPASHMSPRAWRRPTIESHHVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNEREDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAPQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDTGQSFSGKALDVWATGVTLYCFVYGKCPFIDEYILALHRKIKNEAVVFPEEPEVSEELKDLILKMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVKLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLLKEGCGEGGKSPELPGVQEDEAAS

Predicted Molecular Mass
88 kDa
Purity

≥ 95%, as determined by reducing SDS-PAGE.
각종 서류
Handling Instructions (2659 KB)

CAMKK1 Protein, Rat (F230G, sf9, GST) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CAMKK1 Protein, Rat (F230G, sf9, GST)
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HY-P703030
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