98319-26-7
Chemical Structure
Finasteride
Synonym(s): MK-906
- CAS No.: 98319-26-7
- Formula:C23H36N2O2
- Molecular Weight:372.54
IUPAC Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(tert-butyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
InChIKey: DBEPLOCGEIEOCV-WSBQPABSSA-N
SMILES: O=C([C@H]1CC[C@]2([H])[C@]1(C)CC[C@]3([H])[C@@]4(C)C=CC(N[C@]4([H])CC[C@]32[H])=O)NC(C)(C)C
Biological Activity: Finasteride (MK-906) is an orally active and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].
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Finasteride | 99.94% | Finasteride (MK-906) is an orally active and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia. | ||||||||||||||||||||
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Finasteride (Standard) | ≥98% | Finasteride (Standard) is the analytical standard of Finasteride. This product is intended for research and analytical applications. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia. | ||||||||||||||||||||
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Finasteride-d9 | Finasteride-d9 is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia. | |||||||||||||||||||||
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Similarity Score 0.93
HY-13635AFinasteride acetate -
Similarity Score 0.89
HY-139349Finasteride carboxaldehyde -
Similarity Score 0.88
HY-U00125CGP-53153 -
Similarity Score 0.86
HY-W739812Carboxy finasteride -
Similarity Score 0.82
HY-13778R3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid (Standard) -
Similarity Score 0.81
HY-Z8081Dutasteride impurity 1 -
Similarity Score 0.80
HY-106363MK-0963 -
Similarity Score 0.77
HY-108407RDihydrofinasteride (Standard) -
Similarity Score 0.64
![3-((3S,3aS,5aS,6R,9aS,9bS)-3-(Tert-butylcarbamoyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid (Standard) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w727898r.gif)
HY-W727898R3-((3S,3aS,5aS,6R,9aS,9bS)-3-(Tert-butylcarbamoyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid (Standard) -
Explore the MedChemAI to find more analogs
![3-((3S,3aS,5aS,6R,9aS,9bS)-3-(Tert-butylcarbamoyl)-3a,6-dimethyl-7-oxododecahydro-1H-cyclopenta[a]naphthalen-6-yl)propanoic acid (Standard) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w727898r.gif)
References
- [1]. Flores E, et, al. Steroid 5alpha-reductase inhibitors. Mini Rev Med Chem. 2003 May;3(3):225-37. [Content Brief]
- [2]. Yun DK, et, al. Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. Biomol Ther (Seoul). 2013 Jan;21(1):49-53. [Content Brief]
- [3]. Sirinarumitr K, et, al. Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy. J Am Vet Med Assoc. 2001 Apr 15;218(8):1275-80. [Content Brief]
