1. Metabolic Enzyme/Protease
  2. 5 alpha Reductase
  3. Finasteride acetate

Finasteride acetate (Synonyms: MK-906 acetate)

Cat. No.: HY-13635A
Handling Instructions

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia.

For research use only. We do not sell to patients.

Finasteride acetate Chemical Structure

Finasteride acetate Chemical Structure

CAS No. : 222989-99-3

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Description

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

IC50 & Target

IC50: 4.2 nM (type II 5α-reductase)[1]

In Vitro

Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: PC-3, DU-145, and LNCaP cells
Concentration: 10 μM
Incubation Time: 6, 12, 24 h
Result: Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.
In Vivo

Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)[3]
Dosage: 0.1-0.5 mg/kg
Administration: P.o. once daily for 16 weeks
Result: Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
No adverse effects on dogs.
Clinical Trial
Molecular Weight

432.60

Formula

C₂₅H₄₀N₂O₄

CAS No.

222989-99-3

SMILES

CC(O)=O.C[[email protected]@]1([[email protected]]2C(NC(C)(C)C)=O)[[email protected]](CC2)([H])[[email protected]@](CC[[email protected]](N3)([H])[[email protected]@]4(C=CC3=O)C)([H])[[email protected]]4([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FinasterideMK-906MK906MK 9065 alpha Reductase5α-reductasetypeIIbenignprostatichyperplasiaBPHandrogenicalopeciaInhibitorinhibitorinhibit

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Finasteride acetate
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HY-13635A
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