Finasteride acetate
Based on 4 publication(s) in Google Scholar
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia.
For research use only. We do not sell to patients.
- CAS No.: 222989-99-3
- Formula: C25H40N2O4
- Molecular Weight:432.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Finasteride acetate
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In Vivo Efficacy Study
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WB
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Cell Proliferation/Viability Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
Biological Activity
IC50: 4.2 nM (type II 5α-reductase)[1]
Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3, DU-145, and LNCaP cells
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Concentration:10 μM
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Incubation Time:6, 12, 24 h
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Result:Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)[3]
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Dosage:0.1-0.5 mg/kg
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Administration:P.o. once daily for 16 weeks
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Result:Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
No adverse effects on dogs.
Chemical Information
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CAS No. 222989-99-3
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Molecular Weight 432.60
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Formula C25H40N2O4
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SMILES
CC(O)=O.C[C@@]1([C@H]2C(NC(C)(C)C)=O)[C@](CC2)([H])[C@@](CC[C@](N3)([H])[C@@]4(C=CC3=O)C)([H])[C@]4([H])CC1
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Synonyms
MK-906 acetate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Bushen Tongluo formula ameliorated testosterone propionate-induced benign prostatic hyperplasia in rats. [Abstract]2023 Nov:120:155048. PMID: 37651753
Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]
Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased the prostate volume, wet weight, and prostate index of TP-induced BPH rats.
Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]
Protein levels of TGF-β1, vimentin, and E-cadherin were detected by western blot analysis. Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased TGF-β1 expression in the prostate tissues of BPH rats.
Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]
Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d)-spiked serum significantly inhibited the activities of BPH-1 cells at 48, 72, and 96 h compared to the serum of the model group.
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J Transl Med
The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. [Abstract]2023 Feb 2;21(1):71. PMID: 36732752
Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71. [Abstract]
Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the analgesic effects of TPPU in anhedonia-susceptible mice.
Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71. [Abstract]
TSPO antagonist Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the antidepressant effects of TPPU in anhedonia-susceptible mice.
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Sci Rep
Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase. [Abstract]2019 Dec 23;9(1):19703. PMID: 31873149 -
J Pain
Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors. [Abstract]2019 May;20(5):577-591. PMID: 30500366
Purity & Documentation
References
[1]. Flores E, et, al. Steroid 5alpha-reductase inhibitors. Mini Rev Med Chem. 2003 May;3(3):225-37. [Content Brief]
[2]. Yun DK, et, al. Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. Biomol Ther (Seoul). 2013 Jan;21(1):49-53. [Content Brief]
[3]. Sirinarumitr K, et, al. Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy. J Am Vet Med Assoc. 2001 Apr 15;218(8):1275-80. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Finasteride acetate Related Classifications
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