2. Metabolic Enzyme/Protease
  3. 5 alpha Reductase
  4. Finasteride acetate

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia.

For research use only. We do not sell to patients.

CAS No. : 222989-99-3

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Finasteride acetate Related Antibodies

Top Publications Citing Use of Products

    Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048.

    Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased the prostate volume, wet weight, and prostate index of TP-induced BPH rats.

    Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048.

    Protein levels of TGF-β1, vimentin, and E-cadherin were detected by western blot analysis. Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased TGF-β1 expression in the prostate tissues of BPH rats.

    Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048.

    Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d)-spiked serum significantly inhibited the activities of BPH-1 cells at 48, 72, and 96 h compared to the serum of the model group.

    Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71.  [Abstract]

    Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the analgesic effects of TPPU in anhedonia-susceptible mice.

    Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71.  [Abstract]

    TSPO antagonist Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the antidepressant effects of TPPU in anhedonia-susceptible mice.

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    Description

    Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

    IC50 & Target

    IC50: 4.2 nM (type II 5α-reductase)[1]
    In Vitro

    Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
    Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Finasteride acetate Related Antibodies

    Cell Viability Assay[2]

    Cell Line: PC-3, DU-145, and LNCaP cells
    Concentration: 10 μM
    Incubation Time: 6, 12, 24 h
    Result: Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
    Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.
    In Vivo

    Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)[3]
    Dosage: 0.1-0.5 mg/kg
    Administration: P.o. once daily for 16 weeks
    Result: Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
    Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
    No adverse effects on dogs.
    Molecular Weight

    432.60

    Formula

    C25H40N2O4
    CAS No.
    SMILES

    CC(O)=O.C[C@@]1([C@H]2C(NC(C)(C)C)=O)[C@](CC2)([H])[C@@](CC[C@](N3)([H])[C@@]4(C=CC3=O)C)([H])[C@]4([H])CC1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Finasteride acetate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Finasteride222989-99-3MK-906MK906MK 9065 alpha Reductase5α-reductasetypeIIbenignprostatichyperplasiaBPHandrogenicalopeciaInhibitorinhibitorinhibit

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