1. Metabolic Enzyme/Protease
    Apoptosis
  2. 5 alpha Reductase
    Apoptosis
  3. Dutasteride

Dutasteride (Synonyms: GG 745; GI 198745)

Cat. No.: HY-13613 Purity: 99.75%
Handling Instructions

Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.

For research use only. We do not sell to patients.

Dutasteride Chemical Structure

Dutasteride Chemical Structure

CAS No. : 164656-23-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Description

Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT[1].

IC50 & Target

IC50: 5 alpha-reductase[1]

In Vitro

Dutasteride inhibits 3H-T conversion to 3H-DHT and, as anticipated, inhibits T-induced secretion of PSA and proliferation. However the drug also inhibited DHT-induced PSA secretion and cell proliferation (IC50 approximately 1 μM)[1].
Dutasteride competes for binding the LNCaP cell AR with an IC50 approximately 1.5 μM. High concentrations of dutasteride (10-50 μM), but not finasteride, in steroid-free medium, resulted in enhanced cell death, possibly by apoptosis[1].
Dutasteride reduces cell viability and cell proliferation in both cell lines tested (androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer (PCa)) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GG745 has a terminal half-life of approximately 240 hr, and single doses of >10 mg decreased DHT levels significantly more than did single 5-mg doses of finasteride[3].
In placebo treated men without prostate cancer there was an 8.3% median increase in PSA at month 24 compared with -59.5% in those who received dutasteride, using doubled values to correct for dutasteride treatment[4].
Toxicity: Dutasteride may affect male fertility and steroid hormone dynamics. Therefore, a 21-day reproduction study was conducted to determine the effects of dutasteride (10, 32 and 100 μg/L) on fish reproduction. Exposure to dutasteride significantly reduced fecundity of fish and affected several aspects of reproductive endocrine functions in both males and females[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

528.53

Formula

C₂₇H₃₀F₆N₂O₂

CAS No.

164656-23-9

SMILES

O=C([[email protected]]1CC[[email protected]]2([H])[[email protected]]1(C)CC[[email protected]]3([H])[[email protected]@]4(C)C=CC(N[[email protected]]4([H])CC[[email protected]]32[H])=O)NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (63.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8920 mL 9.4602 mL 18.9204 mL
5 mM 0.3784 mL 1.8920 mL 3.7841 mL
10 mM 0.1892 mL 0.9460 mL 1.8920 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DutasterideGG 745 GI 198745GG745GG-745GI198745GI 198745GI-1987455 alpha ReductaseApoptosis5α-reductaseInhibitorinhibitorinhibit

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Dutasteride
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