844464-54-6
Chemical Structure
GIT1-IN-1
- CAS No.: 844464-54-6
- Formula:C21H20N4O4S
- Molecular Weight:424.47
InChIKey: VAXQCCHSGBHNED-UHFFFAOYSA-N
SMILES: O=C(CN1C(C(SC2=C3C=C4C(CC(C)(C)OC4)=N2)=C3N=C1)=O)NCC5=CC=CO5
Biological Activity: GIT1-IN-1 is an inhibitor of ARF GTPase-activating protein 1 (GIT1) with a KD of 6.2 μM. GIT1-IN-1 induces apoptosis (apoptosis) in liver and colon cancer cells, arrests the cell cycle at the G2/M phase, and inhibits cell proliferation, colony formation and migration. GIT1-IN-1 inhibits the activities of MEK and ERK, reduces the expression level of cyclin D1, and stabilizes cyclin B1 protein in liver and colon cancer cells. GIT1-IN-1 can be used in the research of liver cancer and colon cancer[1].
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GIT1-IN-1 | GIT1-IN-1 is an inhibitor of ARF GTPase-activating protein 1 (GIT1) with a KD of 6.2 μM. GIT1-IN-1 induces apoptosis (apoptosis) in liver and colon cancer cells, arrests the cell cycle at the G2/M phase, and inhibits cell proliferation, colony formation and migration. GIT1-IN-1 inhibits the activities of MEK and ERK, reduces the expression level of cyclin D1, and stabilizes cyclin B1 protein in liver and colon cancer cells. GIT1-IN-1 can be used in the research of liver cancer and colon cancer. | |||||||||||||||||||||
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Keywords
