123524-52-7
Chemical Structure
Azelnidipine
Synonym(s): CS 905
- CAS No.: 123524-52-7
- Formula:C33H34N4O6
- Molecular Weight:582.65
IUPAC Name: 3-(1-benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: ZKFQEACEUNWPMT-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)NC(C)=C(C(OC(C)C)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OC3CN(C(C4=CC=CC=C4)C5=CC=CC=C5)C3
Biological Activity: Azelnidipine (CS 905) is a dihydropyridine calcium channel blocker that is effective orally. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects [1] [2] [3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Azelnidipine | 99.79% | Azelnidipine (CS 905) is a dihydropyridine calcium channel blocker that is effective orally. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects . | ||||||||||||||||||||
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Azelnidipine (Standard) | ≥98% | Azelnidipine (Standard) is the analytical standard of Azelnidipine. This product is intended for research and analytical applications. Azelnidipine (CS 905; Calblock) is a dihydropyridine derivative, an L-type calcium channel blocker, and can fight hypertension. | ||||||||||||||||||||
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Azelnidipine-d7 | Azelnidipine-d7 is deuterium labeled Azelnidipine, which is a L-type calcium channel blocker. | |||||||||||||||||||||
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References
- [1]. Ram CVS. Therapeutic Usefulness of a Novel Calcium Channel Blocker Azelnidipine in the Treatment of Hypertension: A Narrative Review. Cardiol Ther. 2022 Dec;11(4):473-489. [Content Brief]
- [2]. Zhao L, et al. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2. Mol Ther Oncolytics. 2022 Sep 26;27:61-72. [Content Brief]
- [3]. Fakharaldeen Z, et al. Potential protective effects of Azelnidipine against cerebral ischemia-reperfusion injury in male rats. J Med Life. 2022 Nov;15(11):1384-1391. [Content Brief]
