2672512-44-4
Chemical Structure
MS432
- CAS No.: 2672512-44-4
- Formula:C50H65F3IN7O6S
- Molecular Weight:1076.06
IUPAC Name: (2S,4R)-1-((S)-20-(tert-butyl)-1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)-1,18-dioxo-3-oxa-2,7,19-triazahenicosan-21-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: KCBAMQOKOLXLOX-BSZYMOERSA-N
SMILES: O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCCCCCCNCCCONC(C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O)=O)=O)C[C@H](O)C1)N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C
Biological Activity: MS432 is a potent and selective MEK1/MEK2 PRORAC degrader. MS432 specifically degrades MEK1 and MEK2 by recruiting the VHL E3 ligase, thereby potently inhibiting the phosphorylation activation of the downstream ERK pathway. MS432 can be used in research related to colorectal cancer and melanoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MS432 | 99.72% | MS432 is a potent and selective MEK1/MEK2 PRORAC degrader. MS432 specifically degrades MEK1 and MEK2 by recruiting the VHL E3 ligase, thereby potently inhibiting the phosphorylation activation of the downstream ERK pathway. MS432 can be used in research related to colorectal cancer and melanoma. | ||||||||||||||||||||
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