1236699-92-5
1236699-92-5
Chemical Structure
Pimasertib
Synonym(s): AS703026; MSC1936369B
- CAS No.: 1236699-92-5
- Formula:C15H15FIN3O3
- Molecular Weight:431.20
IUPAC Name: (S)-N-(2,3-dihydroxypropyl)-3-((2-fluoro-4-iodophenyl)amino)isonicotinamide
InChIKey: VIUAUNHCRHHYNE-JTQLQIEISA-N
SMILES: FC1=C(C=CC(I)=C1)NC2=CN=CC=C2C(NC[C@@H](CO)O)=O
Biological Activity: Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pimasertib | 99.60% | Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-12042APimasertib hydrochloride -
Similarity Score 0.76
![3-[(2-Fluoro-4-iodophenyl)amino]isonicotinic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-66016.gif)
HY-660163-[(2-Fluoro-4-iodophenyl)amino]isonicotinic acid -
Similarity Score 0.63
HY-168288MEK ligand-2 -
Similarity Score 0.58
HY-147369NFATc1-IN-1 -
Similarity Score 0.58
HY-10254RMirdametinib (Standard) -
Similarity Score 0.57
HY-139558Zapnometinib -
Similarity Score 0.55
HY-12062PD318088 -
Similarity Score 0.55
HY-182386Triflocin -
Similarity Score 0.54
HY-468322-Amino-N-(pyridin-3-ylmethyl)benzamide -
Explore the MedChemAI to find more analogs
![3-[(2-Fluoro-4-iodophenyl)amino]isonicotinic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-66016.gif)
References
- [1]. Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol, 2010, 149(4), 537-549. [Content Brief]
- [2]. Park SJ, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8. [Content Brief]
