2. Others MAPK/ERK Pathway Autophagy Apoptosis
  3. Reference Standards MEK Autophagy Apoptosis
  4. Mirdametinib (Standard)

Mirdametinib (Standard)  (Synonyms: PD0325901 (Standard); PD325901 (Standard))

Cat. No.: HY-10254R Purity: 98%
Handling Instructions Technical Support

Mirdametinib (Standard) is the analytical standard of Mirdametinib (HY-10254). This product is intended for research and analytical applications. Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC50 of 0.33 nM. Mirdametinib exhibits a Kiapp of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts.

For research use only. We do not sell to patients.

Mirdametinib (Standard)

Mirdametinib (Standard) Chemical Structure

CAS No. : 391210-10-9

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50 mg Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
100 mg Get quote 4 - 6 Weeks 3 - 5 Weeks 5 - 7 Weeks 4 - 6 weeks
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Information

Mirdametinib (Standard) is the analytical standard of Mirdametinib (HY-10254). This product is intended for research and analytical applications. Mirdametinib (PD0325901) is an orally active, selective and non-ATP-competitive MEK inhibitor with an IC50 of 0.33 nM. Mirdametinib exhibits a Kiapp of 1 nM against activated MEK1 and MEK2. Mirdametinib suppresses the expression of p-ERK1/2 and induces apoptosis. Mirdametinib has anti-cancer activity for a broad spectrum of human tumor xenografts.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

482.19

Formula

C16H14F3IN2O4
CAS No.
SMILES

O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2F)F)NOC[C@H](O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Mirdametinib (Standard) Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mirdametinib (Standard)391210-10-9PD0325901 (Standard) PD325901 (Standard)Reference StandardsMEKAutophagyApoptosisMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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