923032-37-5
923032-37-5
Chemical Structure
Refametinib
Synonym(s): BAY 869766; RDEA119
- CAS No.: 923032-37-5
- Formula:C19H20F3IN2O5S
- Molecular Weight:572.34
IUPAC Name: (S)-N-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
InChIKey: RDSACQWTXKSHJT-NSHDSACASA-N
SMILES: O=S(C1(C[C@H](O)CO)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O
Biological Activity: Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor with IC50s of 19 nM and 47 nM, respectively.
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Refametinib | 99.82% | Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor with IC50s of 19 nM and 47 nM, respectively. | ||||||||||||||||||||
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Refametinib (Standard) | ≥98% | Refametinib (Standard) is the analytical standard of Refametinib. This product is intended for research and analytical applications. Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor with IC50s of 19 nM and 47 nM, respectively. | ||||||||||||||||||||
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Keywords
