Refametinib (R enantiomer)
Based on 1 publication(s) in Google Scholar
Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM.
For research use only. We do not sell to patients.
- CAS No.: 923032-38-6
- Formula: C19H20F3IN2O5S
- Molecular Weight:572.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Refametinib (R enantiomer)
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Biological Activity
Description
IC50 & Target
[1]|
MEK 2-15 nM (EC50) |
In Vitro
Refametinib R enantiomer is the R enantiomer of Refametinib . Refametinib R enantiomer is an inhibitor of MEK and is useful in treatment of cancer and other hyperproliferative diseases[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 923032-38-6
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Molecular Weight 572.34
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Formula C19H20F3IN2O5S
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SMILES
O=S(C1(C[C@H](CO)O)CC1)(NC(C(NC(C(F)=C2)=CC=C2I)=C3F)=C(OC)C=C3F)=O
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Synonyms
BAY 869766 R enantiomer; RDEA119 R enantiomer
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Adv
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. [Abstract]2019 Aug 14;5(8):eaav8463. PMID: 31453322
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Refametinib (R enantiomer) Related Classifications
HY-10216 Related Classifications
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