2. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  3. Microtubule/Tubulin
    Apoptosis
  4. Batabulin sodium

Batabulin sodium  (Synonyms: T138067 sodium)

Cat. No.: HY-13563A Purity: 99.79%
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Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death.

For research use only. We do not sell to patients.

Batabulin sodium Chemical Structure

Batabulin sodium Chemical Structure

CAS No. : 195533-98-3

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10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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10 mg USD 270 In-stock
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50 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Batabulin sodium (T138067 sodium) is an antitumor agent, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin sodium affects cell morphology and leads to cell-cycle arrest ultimately induces apoptotic cell death[1].

IC50 & Target

β-tubulin[1]
In Vitro

Batabulin (T138067; 30-300 nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary[1].
Batabulin (T138067; 30-300 nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100 nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis[1].
Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1, β2, and β4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MCF7 cells
Concentration: 30 nM, 100 nM and 300 nM
Incubation Time: 24 hours
Result: Showed an arrest at the G2/M cell-cycle boundary.

Apoptosis Analysis[1]

Cell Line: MCF7 cells
Concentration: 30 nM, 100 nM and 300 nM
Incubation Time: 24 hours or 48 hours
Result: 25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.
In Vivo

Batabulin (T138067; 40 mg/kg; intraperitoneal injection; once per week; on days 5, 12, and 19; male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; once per week; on days 5, 12, and 19
Result: Impaired the growth of the drug-sensitive CCRF-CEM tumors.
Clinical Trial
Molecular Weight

393.24

Appearance

Solid

Formula

C13H6F6NNaO3S
CAS No.
SMILES

O=S(C1=C(F)C(F)=C(F)C(F)=C1F)([N-]C2=CC=C(OC)C(F)=C2)=O.[Na+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (317.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5430 mL 12.7149 mL 25.4298 mL
5 mM 0.5086 mL 2.5430 mL 5.0860 mL
10 mM 0.2543 mL 1.2715 mL 2.5430 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Batabulin195533-98-3T138067T 138067T-138067Microtubule/TubulinApoptosisAntimitoticβ-tubulinantitumormultidrug-resistantpolymerizationCys-239covalentcytoskeletoncell-cyclearrestInhibitorinhibitorinhibit

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