1187431-43-1
Chemical Structure
Trametinib (DMSO solvate)
Synonym(s): GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)
- CAS No.: 1187431-43-1
- Formula:C28H29FIN5O5S
- Molecular Weight:693.53
IUPAC Name: N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1)
InChIKey: OQUFJVRYDFIQBW-UHFFFAOYSA-N
SMILES: CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O
Biological Activity: Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis[1][2]. This product is in solid form, a DMSO solvate, and a stable crystalline form.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Trametinib (DMSO solvate) | 99.50% | Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis. This product is in solid form, a DMSO solvate, and a stable crystalline form. | ||||||||||||||||||||
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- [1]. Yamaguchi T, et al. Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with HWA486. Inflamm Res, 2012, 61(5), 445-454. [Content Brief]
- [2]. Abe H, et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med Chem Lett. 2011 Feb 28;2(4):320-4. [Content Brief]
Keywords
