1801756-14-8
1801756-14-8
Chemical Structure
KZ-02
- CAS No.: 1801756-14-8
- Formula:C15H11F2IN4O3S
- Molecular Weight:492.24
InChIKey: NCXQEKULAYAEMA-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C(F)=C1NC3=CC=C(C=C3F)I)N=NS2)NOCCO
Biological Activity: KZ-02 is an orally active dual MEK1/Pim-1 kinase inhibitor, with an IC50 of 1.07 nM against MEK1 and an IC50 of 1.34 μM against Pim-1. KZ-02 reduces the phosphorylation levels of ERK and Cdc25C, and promotes the proteasomal degradation of Pim-1 protein. KZ-02 inhibits cancer cell growth and exerts anti-tumor effects. KZ-02 can be used in the research of colorectal cancer[1].
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KZ-02 | KZ-02 is an orally active dual MEK1/Pim-1 kinase inhibitor, with an IC50 of 1.07 nM against MEK1 and an IC50 of 1.34 μM against Pim-1. KZ-02 reduces the phosphorylation levels of ERK and Cdc25C, and promotes the proteasomal degradation of Pim-1 protein. KZ-02 inhibits cancer cell growth and exerts anti-tumor effects. KZ-02 can be used in the research of colorectal cancer. | |||||||||||||||||||||
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References
Keywords
