1168091-68-6
1168091-68-6
Chemical Structure
GDC-0623
Synonym(s): RG 7421; MEK inhibitor 1
- CAS No.: 1168091-68-6
- Formula:C16H14FIN4O3
- Molecular Weight:456.21
IUPAC Name: 5-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
InChIKey: RFWVETIZUQEJEF-UHFFFAOYSA-N
SMILES: FC(C=C(I)C=C1)=C1NC2=C(C(NOCCO)=O)C=CC3=CN=CN23
Biological Activity: GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GDC-0623 | 98.74% | GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). | ||||||||||||||||||||
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Keywords
