1. MAPK/ERK Pathway
    PROTAC
  2. MEK
    Ligand for Target Protein for PROTAC
  3. PD0325901-O-C2-dioxolane

PD0325901-O-C2-dioxolane 

Cat. No.: HY-131295
Handling Instructions

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader.

For research use only. We do not sell to patients.

PD0325901-O-C2-dioxolane Chemical Structure

PD0325901-O-C2-dioxolane Chemical Structure

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Description

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].

IC50 & Target[1]

MEK1

 

MEK2

 

In Vitro

PD0325901 is a non-ATP competitive MEK inhibitor, potently inhibits ERK signaling and proliferation of tumor cells[1].

Molecular Weight

508.23

Formula

C₁₈H₁₆F₃IN₂O₄

SMILES

O=C(NOCCC1OCCO1)C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PD0325901-O-C2-dioxolaneMEKLigand for Target Protein for PROTACMitogen-activated protein kinase kinaseMAPKKMAP2KTarget Protein-binding MoietyPROTACEligandE3ligasecolorectalcancermelanomaproliferationInhibitorinhibitorinhibit

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Product Name:
PD0325901-O-C2-dioxolane
Cat. No.:
HY-131295
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