1. MAPK/ERK Pathway
  2. MEK
  3. GW284543 hydrochloride

GW284543 hydrochloride  (Synonyms: UNC10225170 hydrochloride)

Cat. No.: HY-114189A
Handling Instructions

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.

For research use only. We do not sell to patients.

GW284543 hydrochloride Chemical Structure

GW284543 hydrochloride Chemical Structure

CAS No. : 179246-08-3

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Description

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

IC50 & Target[1]

MEK5

 

In Vitro

GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 cells
Concentration: 10 and 20 μM
Incubation Time: 6 hours
Result: Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
Molecular Weight

408.88

Formula

C23H21ClN2O3

CAS No.
SMILES

COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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GW284543 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
GW284543 hydrochloride
Cat. No.:
HY-114189A
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