GW284543 hydrochloride
Based on 1 publication(s) in Google Scholar
GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein.
For research use only. We do not sell to patients.
- CAS No.: 179246-08-3
- Formula: C23H21ClN2O3
- Molecular Weight:408.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) GW284543 hydrochloride
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Biological Activity
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MEK5 |
GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MIA PaCa-2 cells
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Concentration:10 and 20 μM
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Incubation Time:6 hours
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Result:Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
Chemical Information
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CAS No. 179246-08-3
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Molecular Weight 408.88
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Formula C23H21ClN2O3
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SMILES
COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC.Cl
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Synonyms
UNC10225170 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Oncol (Dordr)
The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells. [Abstract]2025 Jun;48(3):789-799. PMID: 39998753
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GW284543 hydrochloride Related Classifications
HY-114189A Related Classifications
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