LB-60-OF61

Cat. No.: HY-101280 Purity: 99.25%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.

For research use only. We do not sell to patients.

LB-60-OF61 Chemical Structure

CAS No. : 794461-93-1

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 638	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 638	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1900	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 5000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
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Description

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines^[1].

IC₅₀ & Target

NAMPT^[1]

In Vitro

LB-60-OF61 is potent against HCT116 cells with an IC₅₀ around 30 nM as measured in a 384 well format^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

494.59

Formula

C₂₉H₃₀N₆O₂

CAS No.

794461-93-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=C(OCC2=CC3=C(N=C(C#N)N=C3)N2CCC4CCCCC4)C=C1)NCC5=CC=CN=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (404.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0219 mL	10.1094 mL	20.2188 mL
5 mM	0.4044 mL	2.0219 mL	4.0438 mL
10 mM	0.2022 mL	1.0109 mL	2.0219 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (248 KB) HNMR (394 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0219 mL	10.1094 mL	20.2188 mL	50.5469 mL
	5 mM	0.4044 mL	2.0219 mL	4.0438 mL	10.1094 mL
	10 mM	0.2022 mL	1.0109 mL	2.0219 mL	5.0547 mL
	15 mM	0.1348 mL	0.6740 mL	1.3479 mL	3.3698 mL
	20 mM	0.1011 mL	0.5055 mL	1.0109 mL	2.5273 mL
	25 mM	0.0809 mL	0.4044 mL	0.8088 mL	2.0219 mL
	30 mM	0.0674 mL	0.3370 mL	0.6740 mL	1.6849 mL
	40 mM	0.0505 mL	0.2527 mL	0.5055 mL	1.2637 mL
	50 mM	0.0404 mL	0.2022 mL	0.4044 mL	1.0109 mL
	60 mM	0.0337 mL	0.1685 mL	0.3370 mL	0.8424 mL
	80 mM	0.0253 mL	0.1264 mL	0.2527 mL	0.6318 mL
	100 mM	0.0202 mL	0.1011 mL	0.2022 mL	0.5055 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LB-60-OF61794461-93-1Inhibitorinhibitorinhibit

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