BET-IN-20
BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage.
For research use only. We do not sell to patients.
- CAS No.: 1300735-76-5
- Formula: C25H24N4O2
- Molecular Weight:412.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 1.9 nM (BRD4 BD1)[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
2.08 μM
Compound: 10
|
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 37992518] |
| MM1.S | IC50 |
0.53 μM
Compound: 10
|
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 37992518] |
| MOLM-13 | IC50 |
0.43 μM
Compound: 10
|
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 37992518] |
| MV4-11 | IC50 |
0.19 μM
Compound: 10
|
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 37992518] |
Chemical Information
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CAS No. 1300735-76-5
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Molecular Weight 412.48
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Formula C25H24N4O2
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SMILES
C[C@H](C1=CC=CC=C1)N2C(C3=C4)=C(N=C2C)C=NC3=CC(C5=C(C)ON=C5C)=C4OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)