1300735-76-5
1300735-76-5
Chemical Structure
BET-IN-20
- CAS No.: 1300735-76-5
- Formula:C25H24N4O2
- Molecular Weight:412.48
InChIKey: LJVBCQJBIHMYGJ-OAHLLOKOSA-N
SMILES: C[C@H](C1=CC=CC=C1)N2C(C3=C4)=C(N=C2C)C=NC3=CC(C5=C(C)ON=C5C)=C4OC
Biological Activity: BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage[1].
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BET-IN-20 | BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage. | |||||||||||||||||||||
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References
Keywords
