1. MAPK/ERK Pathway
  2. p38 MAPK
  3. Ralimetinib

Ralimetinib (Synonyms: LY2228820)

Cat. No.: HY-13241A
Handling Instructions

Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.

For research use only. We do not sell to patients.

Ralimetinib Chemical Structure

Ralimetinib Chemical Structure

CAS No. : 862505-00-8

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Description

Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc[1].

IC50 & Target[1]

p38β MAPK

3.2 nM (IC50)

p38α MAPK

5.3 nM (IC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

420.53

Formula

C₂₄H₂₉FN₆

CAS No.

862505-00-8

SMILES

NC1=NC2=CC=C(C3=C(C4=CC=C(F)C=C4)N=C(C(C)(C)C)N3)N=C2N1CC(C)(C)C

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Room temperature in continental US; may vary elsewhere

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Product Name:
Ralimetinib
Cat. No.:
HY-13241A
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Ralimetinib

Cat. No.: HY-13241A