2. Apoptosis
  3. c-Myc Apoptosis
  4. MYC-RIBOTAC

MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) to MYC internal ribosome entry site (IRES).MYC-RIBOTAC contains a MYC mRNA-binder and a small molecule that recruits and locally activates RNase L1 and decreases the mRNA and protein expression levels of MYC, induces apoptosis. MYC-RIBOTAC can be used for anticancer research.

For research use only. We do not sell to patients.

MYC-RIBOTAC Chemical Structure

MYC-RIBOTAC Chemical Structure

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1 mg USD 545 In-stock
5 mg USD 1200 In-stock
10 mg USD 1920 In-stock
25 mg USD 4035 In-stock
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Based on 1 publication(s) in Google Scholar

MYC-RIBOTAC Related Antibodies

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Description

MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) to MYC internal ribosome entry site (IRES).MYC-RIBOTAC contains a MYC mRNA-binder and a small molecule that recruits and locally activates RNase L1 and decreases the mRNA and protein expression levels of MYC, induces apoptosis. MYC-RIBOTAC can be used for anticancer research[1].

In Vitro

MYC-RIBOTAC (0-10 μM; 48 hours) decreases the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L dependent manner[1].
MYC-RIBOTAC (0-10 μM; 48 hours) has antiproliferative and induce-apoptotic effects in HeLa cells and Namalwa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MYC-RIBOTAC Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HeLa cells and Namalwa cells
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Had antiproliferative and induce-apoptotic effects in in HeLa cells.
Induced cell cycle arrest and provoked apoptosis and reduced colony formation by about 50% in Namalwa cells.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Decreased the abundance of MYC mRNA in HeLa cells in a dose-dependent and RNase L dependent manner, up to around 50% at a 10 μM dose with a concomitant reduction in MYC protein levels.
Molecular Weight

1067.17

Formula

C55H58N10O11S
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (93.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9371 mL 4.6853 mL 9.3706 mL
5 mM 0.1874 mL 0.9371 mL 1.8741 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9371 mL 4.6853 mL 9.3706 mL 23.4264 mL
5 mM 0.1874 mL 0.9371 mL 1.8741 mL 4.6853 mL
10 mM 0.0937 mL 0.4685 mL 0.9371 mL 2.3426 mL
15 mM 0.0625 mL 0.3124 mL 0.6247 mL 1.5618 mL
20 mM 0.0469 mL 0.2343 mL 0.4685 mL 1.1713 mL
25 mM 0.0375 mL 0.1874 mL 0.3748 mL 0.9371 mL
30 mM 0.0312 mL 0.1562 mL 0.3124 mL 0.7809 mL
40 mM 0.0234 mL 0.1171 mL 0.2343 mL 0.5857 mL
50 mM 0.0187 mL 0.0937 mL 0.1874 mL 0.4685 mL
60 mM 0.0156 mL 0.0781 mL 0.1562 mL 0.3904 mL
80 mM 0.0117 mL 0.0586 mL 0.1171 mL 0.2928 mL
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MYC-RIBOTAC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MYC-RIBOTACc-MycApoptosisMycBioactive DegradersHelaNamalwa CellsIRESAnticancerInhibitorinhibitorinhibit

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