Amino-PEG4-alcohol

Name: Amino-PEG4-alcohol
Brand: MedChemExpress
SKU: HY-W008005
Rating: 4.5 (1 reviews)

Cat. No.: HY-W008005 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Amino-PEG4-alcohol Chemical Structure

CAS No. : 86770-74-3

Size	Price	Stock	Quantity
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
1 g	USD 50	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs^[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[2].

IC₅₀ & Target^[1]

PEGs	Non-cleavable Linker

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

193.24

Formula

C₈H₁₉NO₄

CAS No.

86770-74-3

Appearance

Liquid

SMILES

NCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (517.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (517.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1749 mL	25.8746 mL	51.7491 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (517.49 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (240 KB) HNMR (124 KB) GC (87 KB)

Handling Instructions (2659 KB)

References

[1]. Nello Mainolfi, et al. Protein degraders and uses thereof. WO2019060742A1.

[2]. Miller MA, et al. Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation. ACS Nano. 2018 Dec 26;12(12):12814-12826. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.1749 mL	25.8746 mL	51.7491 mL	129.3728 mL
	5 mM	1.0350 mL	5.1749 mL	10.3498 mL	25.8746 mL
	10 mM	0.5175 mL	2.5875 mL	5.1749 mL	12.9373 mL
	15 mM	0.3450 mL	1.7250 mL	3.4499 mL	8.6249 mL
	20 mM	0.2587 mL	1.2937 mL	2.5875 mL	6.4686 mL
	25 mM	0.2070 mL	1.0350 mL	2.0700 mL	5.1749 mL
	30 mM	0.1725 mL	0.8625 mL	1.7250 mL	4.3124 mL
	40 mM	0.1294 mL	0.6469 mL	1.2937 mL	3.2343 mL
	50 mM	0.1035 mL	0.5175 mL	1.0350 mL	2.5875 mL
	60 mM	0.0862 mL	0.4312 mL	0.8625 mL	2.1562 mL
	80 mM	0.0647 mL	0.3234 mL	0.6469 mL	1.6172 mL
	100 mM	0.0517 mL	0.2587 mL	0.5175 mL	1.2937 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.