1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. Amino-PEG4-alcohol

Amino-PEG4-alcohol 

Cat. No.: HY-W008005
Handling Instructions

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Amino-PEG4-alcohol Chemical Structure

Amino-PEG4-alcohol Chemical Structure

CAS No. : 86770-74-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg USD 65 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1]

PEGs

 

Non-cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Molecular Weight

193.24

Formula

C₈H₁₉NO₄

CAS No.

86770-74-3

SMILES

NCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

Amino-PEG4-alcoholPROTAC LinkerADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Amino-PEG4-alcohol
Cat. No.:
HY-W008005
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