2. Anti-infection
  3. HCV
  4. NCI-B16

NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication.

For research use only. We do not sell to patients.

NCI-B16 Chemical Structure

NCI-B16 Chemical Structure

CAS No. : 802835-01-4

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10 mg USD 800 In-stock
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NCI-B16 Related Antibodies

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Description

NCI-B16 is a small molecule RNA binder and inhibits HCV viral replication[1].

Molecular Weight

526.55

Formula

C27H26N8O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(NC(NC4=CC=C(C5=NCCN5)C=C4)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8992 mL 9.4958 mL 18.9915 mL
5 mM 0.3798 mL 1.8992 mL 3.7983 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8992 mL 9.4958 mL 18.9915 mL 47.4789 mL
5 mM 0.3798 mL 1.8992 mL 3.7983 mL 9.4958 mL
10 mM 0.1899 mL 0.9496 mL 1.8992 mL 4.7479 mL
15 mM 0.1266 mL 0.6331 mL 1.2661 mL 3.1653 mL
20 mM 0.0950 mL 0.4748 mL 0.9496 mL 2.3739 mL
25 mM 0.0760 mL 0.3798 mL 0.7597 mL 1.8992 mL
30 mM 0.0633 mL 0.3165 mL 0.6331 mL 1.5826 mL
40 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1870 mL
50 mM 0.0380 mL 0.1899 mL 0.3798 mL 0.9496 mL
60 mM 0.0317 mL 0.1583 mL 0.3165 mL 0.7913 mL
80 mM 0.0237 mL 0.1187 mL 0.2374 mL 0.5935 mL
100 mM 0.0190 mL 0.0950 mL 0.1899 mL 0.4748 mL
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NCI-B16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCI-B16802835-01-4HCVHepatitis C virusRNA binderviral replicationInhibitorinhibitorinhibit

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