NC-III-49-1
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc.
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- CAS No.: 3031654-46-0
- Formule: C44H50N4O11S2
- Masse moléculaire:875.02
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
BRD4-1 0.095 nM (Kd) |
BRD4-2 0.032 nM (Kd) |
BRD4-T 0.29 nM (Kd) |
BRDT-1 0.089 nM (Kd) |
BRDT-2 5.5 nM (Kd) |
BRDT-T 0.058 nM (Kd) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MM1.S | IC50 |
0.69 nM
Compound: NC-III-49-1
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Growth inhibition of human MM1.S cells incubated for 72 hrs by CellTiter-Blue assay
Growth inhibition of human MM1.S cells incubated for 72 hrs by CellTiter-Blue assay
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[PMID: 35867655] |
In Vitro
NC-III-49-1 (0-10 µM; 72 h) shows antiproliferative activity with an IC50 value of 0.69 nM in MM1.S cells[1].
NC-III-49-1 (0-10 µM; 6 h) decreases the expression of c-Myc in a dose dependent manner[1].
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NC-III-49-1 shows inhibition by interact with both KAc sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM1.S cells
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Concentration:0-10 µM
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Incubation Time:72 h
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Result:Showed subnanomolar growth inhibition with an IC50 value of 0.69 nM in multiple myeloma MM1.S cells.
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Cell Line:MM1.S cells
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Concentration:0-10 µM
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Incubation Time:6 h
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Result:Decreased the expression of c-Myc in a dose dependent manner.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3031654-46-0
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Masse moléculaire 875.02
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Formule C44H50N4O11S2
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SMILES
CCS(=O)(NC1=CC=C(C(C(C2=C3C=CC=C2)=CN(C3=O)C)=C1)OCCOCCOCCOCCOC4=CC=C(C=C4C(C5=C6C=CC=C5)=CN(C6=O)C)NS(CC)(=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NC-III-49-1 Related Classifications
HY-150683 Related Classifications
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